

| 货号 | JN856117 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Staphylococcus aureus |
| 应用 | ELISA, FCM, WB |
| 宿主 | Mouse |
| 同种型 | IgG2a |
| 克隆号 | SAA1452 |
| 偶联物 | FITC |
| 克隆类型 | Monoclonal |
| 靶标 | spa, Immunoglobulin G-binding protein A, Staphylococcal protein A |
| 内毒素水平 | Please contact with the lab for this information. |
| 相关产品 | Mouse IgG2a Recombinant Isotype Control Antibody (C1.18.4), FITC |
| Accession号 | P38507 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | Immunoglobulin G-binding protein A (SPA) is a ~55 kDa protein. Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin. |
| Note | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |





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