| 背景 | Integrin beta-3 (Integrin αVβ3 (CD51/ITGAV & CD61) is a ~87 kDa protein. Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. 1. Si-Tahar, M. et al. (1997) The Journal of biological chemistry 272, 11636-47. PMID: 91110812. Fujita, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 5809-19. PMID: 231254154. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 206827785. Mori, S. et al. (2008) The Journal of biological chemistry 283, 18066-75. PMID: 184413247. Saegusa, J. et al. (2009) The Journal of biological chemistry 284, 24106-14. PMID: 195781198. Cedano Prieto, DM. et al. (2017) PloS one 12, e0184285. PMID: 288734649. Takada, YK. et al. (2017) The Journal of biological chemistry 292, 20067-20075. PMID: 2903043010. Saegusa, J. et al. (2008) The Journal of biological chemistry 283, 26107-15. PMID: 18635536 |
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