Anti-Human CD107a/LAMP1 Recombinant Antibody (Mab1), APC (HY332137)

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货号	HY332137
品牌	abinScience
种属反应性	Human
应用	FCM
宿主	Mouse
同种型	IgG1, kappa
克隆号	Mab1
偶联物	APC
克隆类型	Monoclonal
经测试应用	FCM
靶标	LAMP1, Lysosome-associated membrane protein 1, CD107 antigen-like family member A, CD107a, LAMP-1, Lysosome-associated membrane glycoprotein 1
内毒素水平	Please contact with the lab for this information.
相关产品	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
Accession号	P11279
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Lysosome-associated membrane glycoprotein 1 (CD107a/LAMP1) is a ~44 kDa protein. Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. 1. Zhang, J. et al. (2023) Molecular cell 83, 2524-2539.e7. PMID: 37390818 2. Peters, PJ. et al. (1991) The Journal of experimental medicine 173, 1099-109. PMID: 2022921 3. Krzewski, K. et al. (2013) Blood 121, 4672-83. PMID: 23632890 4. Cohnen, A. et al. (2013) Blood 122, 1411-8. PMID: 23847195 5. Sawada, R. et al. (1993) The Journal of biological chemistry 268, 12675-81. PMID: 7685349
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Flow CytoMetry

Flow-cytometry using APC anti-human CD107a antibody. Hela cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD107a monoclonal antibody (Catalog: HY332137, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

产品说明书

Anti-Human CD107a/LAMP1 Recombinant Antibody (Mab1), APC.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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C₁ × V₁ = C₂ × V₂

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C₁ (起始浓度)

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Anti-Human CD107a/LAMP1 Recombinant Antibody (Mab1), APC (HY332137)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CD107a/LAMP1 Recombinant Antibody (Mab1), APC (HY332137)

概述

图片

参考文献

产品说明书

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