

| 货号 | HB738137 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, FCM, IF, WB |
| 宿主 | Mouse |
| 同种型 | IgG2a |
| 克隆号 | SAA0832 |
| 偶联物 | APC |
| 克隆类型 | Monoclonal |
| 靶标 | Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, EPHA2, Ephrin type-A receptor 2, ECK |
| 内毒素水平 | Please contact with the lab for this information. |
| 相关产品 | Mouse IgG2a Recombinant Isotype Control Antibody (C1.18.4), APC |
| Accession号 | P29317 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | Ephrin type-A receptor 2 (EPHA2) is a ~108 kDa protein. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. |
| Note | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |

24小时产品查询

扫一扫关注我们

专属渠道经理