| 货号 | HX206137 |
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| 品牌 | abinScience |
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| 种属反应性 | Human |
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| 应用 | FCM |
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| 宿主 | Human |
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| 同种型 | IgG4, kappa |
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| 克隆号 | SAA0067 |
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| 偶联物 | APC |
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| 克隆类型 | Monoclonal |
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| 靶标 | Stromal cell-derived factor 1 receptor, LCR1, HM89, LPS-associated protein 3, LAP-3, CXC-R4, CXCR-4, SDF-1 receptor, CD184, NPYRL, LESTR, Fusin, FB22, C-X-C chemokine receptor type 4, CXCR4, Lipopolysaccharide-associated protein 3, Leukocyte-derived seven transmembrane domain receptor |
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| 内毒素水平 | Please contact with the lab for this information. |
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| 相关产品 |
Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), APC
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| Accession号 | P61073 |
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| 状态 | Liquid |
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| 保存溶液 |
0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
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| 稳定性和存储 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
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| 背景 | C-X-C chemokine receptor type 4 (CD184/CXCR4) is a ~39 kDa protein. Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CXCR4 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. 1. Brelot, A. et al. (1999) Journal of virology 73, 2576-86. PMID: 100741022. Gupta, SK. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 2368-72. PMID: 104529683. Cheng, ZJ. et al. (2000) The Journal of biological chemistry 275, 2479-85. PMID: 106447024. Brelot, A. et al. (2000) The Journal of biological chemistry 275, 23736-44. PMID: 108251585. Veldkamp, CT. et al. (2008) Science signaling 1, ra4. PMID: 187994246. Busillo, JM. et al. (2010) The Journal of biological chemistry 285, 7805-17. PMID: 200481537. Malik, R. et al. (2010) Molecular biology of the cell 21, 2529-41. PMID: 205050729. Lear, T. et al. (2017) American journal of physiology. Cell physiology 313, C584-C592. PMID: 28978524 |
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| Note | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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