Anti-Mouse Notch-2/Notch-3 Recombinant Antibody (59R1), APC (MC513137)

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货号	MC513137
品牌	abinScience
种属反应性	Human, Mouse
应用	ELISA, FCM
宿主	Rat
同种型	IgG1, kappa
克隆号	59R1
偶联物	APC
克隆类型	Monoclonal
靶标	N2ICD, N2ECD, NOTCH2, hN2, Neurogenic locus notch homolog protein 2, Notch 2, Neurogenic locus notch homolog protein 3, NOTCH3, Notch 3
内毒素水平	Please contact with the lab for this information.
相关产品	Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), APC
Accession号	O35516, Q61982
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Neurogenic locus notch homolog protein 2 (NOTCH2/NOTCH3) is a ~265 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. 1. Hamada, Y. et al. (1999) Development (Cambridge, England) 126, 3415-24. PMID: 10393120 2. Fukushima, H. et al. (2008) Molecular and cellular biology 28, 6402-12. PMID: 18710934
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

产品说明书

Anti-Mouse Notch-2/Notch-3 Recombinant Antibody (59R1), APC.pdf

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Anti-Mouse Notch-2/Notch-3 Recombinant Antibody (59R1), APC (MC513137)

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Anti-Mouse Notch-2/Notch-3 Recombinant Antibody (59R1), APC (MC513137)

概述

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参考文献

产品说明书

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