Anti-Human CD27 Ligand/TNFSF7/CD70 Recombinant Antibody (5F24), PerCP (HB796247)

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货号	HB796247
品牌	abinScience
种属反应性	Human
应用	FCM, WB
宿主	Mouse
同种型	IgG2a, kappa
克隆号	5F24
偶联物	PerCP
克隆类型	Monoclonal
靶标	CD27L receptor, TNFRSF7, T14, CD27 antigen, Tumor necrosis factor receptor superfamily member 7, CD27, T-cell activation antigen CD27
内毒素水平	Please contact with the lab for this information.
相关产品	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), PerCP
Accession号	P26842
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	CD27 antigen is a ~29 kDa protein. Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue. 1. Izawa, K. et al. (2017) The Journal of experimental medicine 214, 73-89. PMID: 28011863 2. Jaeger-Ruckstuhl, CA. et al. (2024) Immunity 57, 287-302.e12. PMID: 38354704
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

产品说明书

Anti-Human CD27 Ligand/TNFSF7/CD70 Recombinant Antibody (5F24), PerCP.pdf

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Anti-Human CD27 Ligand/TNFSF7/CD70 Recombinant Antibody (5F24), PerCP (HB796247)

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图片

参考文献

产品说明书

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Anti-Human CD27 Ligand/TNFSF7/CD70 Recombinant Antibody (5F24), PerCP (HB796247)

概述

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参考文献

产品说明书

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