| 背景 | Leukocyte surface antigen CD47 (MER6) is a ~35 kDa protein. Adhesive protein that mediates cell-to-cell interactions. Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins. Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation. Plays a role in modulating pulmonary endothelin EDN1 signaling. Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure. CD47 is the therapeutic target of magrolimab (clinical). 1. Latour, S. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 2547-54. PMID: 115095943. Isenberg, JS. et al. (2009) The Journal of biological chemistry 284, 1116-25. PMID: 190048354. Lindberg, FP. et al. (1993) The Journal of cell biology 123, 485-96. PMID: 76918315. Gao, AG. et al. (1996) The Journal of biological chemistry 271, 21-4. PMID: 85505626. Rogers, NM. et al. (2017) Cardiovascular research 113, 15-29. PMID: 27742621 |
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