

| 货号 | HY232127 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, FCM |
| 宿主 | Mouse |
| 同种型 | IgG2a, kappa |
| 克隆号 | SAA0436 |
| 偶联物 | PE |
| 克隆类型 | Monoclonal |
| 靶标 | Endothelial cell growth factor, HBGF-1, Fibroblast growth factor 1, FGF1, ECGF, Acidic fibroblast growth factor, aFGF, Heparin-binding growth factor 1, FGF-1, FGFA |
| 内毒素水平 | Please contact with the lab for this information. |
| 相关产品 | Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), PE |
| Accession号 | P05230 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | Fibroblast growth factor 1 (FGF1/aFGF) is a ~17 kDa protein. Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. 1. Mori, S. et al. (2008) The Journal of biological chemistry 283, 18066-75. PMID: 18441324 2. Yamaji, S. et al. (2010) PloS one 5, e10273. PMID: 20422052 3. Mori, S. et al. (2013) PloS one 8, e57927. PMID: 23469107 |
| Note | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |

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