Anti-Human TIGIT Recombinant Antibody (SAA0153), PE (HS739127)

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货号	HS739127
品牌	abinScience
种属反应性	Human
应用	FCM
宿主	Human
同种型	IgG1, kappa
克隆号	SAA0153
偶联物	PE
克隆类型	Monoclonal
靶标	VSTM3, TIGIT, V-set and transmembrane domain-containing protein 3, VSIG9, V-set and immunoglobulin domain-containing protein 9, T-cell immunoreceptor with Ig and ITIM domains
内毒素水平	Please contact with the lab for this information.
相关产品	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), PE
Accession号	Q495A1
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades. _x005F_x000D_ _x005F_x000D_ 1. Yu, X. et al. (2009) Nature immunology 10, 48-57. PMID: 19011627 _x005F_x000D_ _x005F_x000D_ 2. Liu, S. et al. (2013) Cell death and differentiation 20, 456-64. PMID: 23154388 _x005F_x000D_ _x005F_x000D_ 3. Li, M. et al. (2014) The Journal of biological chemistry 289, 17647-57. PMID: 24817116 _x005F_x000D_ _x005F_x000D_ 4. Reches, A. et al. (2020) Journal for immunotherapy of cancer 8. PMID: 32503945
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

产品说明书

Anti-Human TIGIT Recombinant Antibody (SAA0153), PE.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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C₁ × V₁ = C₂ × V₂

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C₁ (起始浓度)

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Anti-Human TIGIT Recombinant Antibody (SAA0153), PE (HS739127)

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Anti-Human TIGIT Recombinant Antibody (SAA0153), PE (HS739127)

概述

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参考文献

产品说明书

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