Anti-Human PCSK9 Recombinant Antibody (SAA0158), PE (HV275127)

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货号	HV275127
品牌	abinScience
种属反应性	Human
应用	FCM
宿主	Human
同种型	IgG2, lambda
克隆号	SAA0158
偶联物	PE
克隆类型	Monoclonal
靶标	Proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9, NARC-1, PC9, Proprotein convertase 9, Neural apoptosis-regulated convertase 1, NARC1, PCSK9
内毒素水平	Please contact with the lab for this information.
相关产品	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10), PE
Accession号	Q8NBP7
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a ~74 kDa protein. Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. PCSK9 is the therapeutic target of evolocumab (Repatha). _x000D_ _x000D_ 1. Poirier, S. et al. (2008) The Journal of biological chemistry 283, 2363-72. PMID: 18039658 _x000D_ _x000D_ 2. Nassoury, N. et al. (2007) Traffic (Copenhagen, Denmark) 8, 718-32. PMID: 17461796 _x000D_ _x000D_ 3. Fan, D. et al. (2008) Biochemistry 47, 1631-9. PMID: 18197702 _x000D_ _x000D_ 4. Mayer, G. et al. (2008) The Journal of biological chemistry 283, 31791-801. PMID: 18799458 _x000D_ _x000D_ 5. Chen, Y. et al. (2011) Biochemical and biophysical research communications 415, 515-8. PMID: 22074827 _x000D_ _x000D_ 6. Jonas, MC. et al. (2008) EMBO reports 9, 916-22. PMID: 18660751
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

产品说明书

Anti-Human PCSK9 Recombinant Antibody (SAA0158), PE.pdf

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Anti-Human PCSK9 Recombinant Antibody (SAA0158), PE (HV275127)

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Anti-Human PCSK9 Recombinant Antibody (SAA0158), PE (HV275127)

概述

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参考文献

产品说明书

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