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Anti-Adalimumab Neutralizing Antibody ELISA kit (AF879048)

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  • 96T
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  • 产品说明书

概述
货号AF879048
品牌abinScience
描述
Anti-Adalimumab Neutralizing Antibody ELISA kit (AF879048) — Quantitative competitive ELISA for Anti-Adalimumab Neutralizing Antibody. Sample: Plasma, Serum. Range: 15.625-1, 000 ng/ml.
Highlights
  • ●Competitive Format — High specificity, reliable quantification.
  • ●Ready-to-Use — Complete kit with pre-coated plates included.
样本类型Plasma, Serum
灵敏度10.94 ng/ml
检测范围31.25-2000 ng/ml
Accession号P01375
应用ELISA
检测方法Colorimetric
实验类型Quantitative
回收率80-120%
运输2-8 ℃
稳定性和存储The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
规格

Adalimumab

别名ABP 501, D2E7, Adalimumab, 331731-18-1
背景

Tumor necrosis factor (Adalimumab) is a ~25 kDa protein. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective.

1. Nie, H. et al. (2013) Nature medicine 19, 322-8. PMID: 23396208
2. Friedmann, E. et al. (2006) Nature cell biology 8, 843-8. PMID: 16829952
3. Jinesh G, G. et al. (2012) Journal of leukocyte biology 92, 233-44. PMID: 22517918
4. Nakahara, H. et al. (2003) Arthritis and rheumatism 48, 1521-9. PMID: 12794819
NoteFor Research Use Only.
图片

  • Standard Curve

    Standard Curve of Anti-Adalimumab Neutralizing Antibody ELISA kit

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Adalimumab Neutralizing Antibody ELISA kit

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