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Anti-Tiragolumab ELISA Kit (AS739018)

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概述
货号AS739018
品牌abinScience
描述
Anti-Tiragolumab ELISA Kit (AS739018) — Quantitative sandwich ELISA for Anti-Tiragolumab. Sample: Plasma, Serum. Range: 156.25 - 10, 000 ng/mL. Sensitivity: 10.11 ng/mL.
Highlights
  • ●Sandwich Format — High specificity, reliable quantification.
  • ●High Sensitivity — Optimized for low-abundance target detection.
  • ●Ready-to-Use — Complete kit with pre-coated plates included.
样本类型Plasma, Serum
灵敏度10.11 ng/mL
检测范围156.25 - 10, 000 ng/mL
Accession号Q495A1
应用ELISA
检测方法Colorimetric
实验类型Quantitative
回收率80-120%
运输2-8 ℃
稳定性和存储When the kit was stored at the recommended temperature for 6 months, the signal intensity decreased by less than 20%. For unopened kits, if you want to prolong the storage time, please store the Standard, Detection A, Detection B and Microplate at - 20℃, the rest reagents should be store at 4℃.
规格

Tiragolumab

别名MTIG-7192-A, MTIG-7192A, MTIG7192A, RG-6058, RO-7092284, RO7092284, 1918185-84-8
背景

T-cell immunoreceptor with Ig and ITIM domains (Tiragolumab) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades.

1. Yu, X. et al. (2009) Nature immunology 10, 48-57. PMID: 19011627
2. Liu, S. et al. (2013) Cell death and differentiation 20, 456-64. PMID: 23154388
3. Li, M. et al. (2014) The Journal of biological chemistry 289, 17647-57. PMID: 24817116
4. Reches, A. et al. (2020) Journal for immunotherapy of cancer 8. PMID: 32503945
NoteFor Research Use Only.
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参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Tiragolumab ELISA Kit

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