| 稳定性和存储 | When the kit was stored at the recommended temperature for 6 months, the signal intensity decreased by less than 20%. For unopened kits, if you want to prolong the storage time, please store the Standard, Detection A, Detection B and Microplate at - 20℃, the rest reagents should be store at 4℃. |
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| 背景 | Spike glycoprotein (Imdevimab) is a ~141 kDa protein. Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2. When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane. When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis using host TFRC and GRM2 and leading to fusion of the virion membrane with the host endosomal membrane. Alternatively, may use NRP1/NRP2 and integrin as entry receptors. 3. Cao, W. et al. (2021) Biophysical journal 120, 1011-1019. PMID: 336070864. Takeda, M. (2022) Microbiology and immunology 66, 15-23. PMID: 345618875. Wrapp, D. et al. (2020) Science (New York, N.Y.) 367, 1260-1263. PMID: 320758776. Ou, X. et al. (2020) Nature communications 11, 1620. PMID: 322213068. Wang, X. et al. (2023) Journal of virology 97, e0161122. PMID: 367797639. Daly, JL. et al. (2020) Science (New York, N.Y.) 370, 861-865. PMID: 3308229410. Cantuti-Castelvetri, L. et al. (2020) Science (New York, N.Y.) 370, 856-860. PMID: 33082293 |
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