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Eldelumab ELISA Kit (DY524018)

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概述
货号DY524018
品牌abinScience
描述
Eldelumab ELISA Kit (DY524018) — Quantitative sandwich ELISA for Eldelumab. Sample: Plasma, Serum. Range: 0.31-5 μg/mL. Sensitivity: 0.156 μg/ml.
Highlights
  • ●Sandwich Format — High specificity, reliable quantification.
  • ●High Sensitivity — Optimized for low-abundance target detection.
  • ●Ready-to-Use — Complete kit with pre-coated plates included.
样本类型Plasma, Serum
灵敏度0.156 μg/ml
检测范围0.31-5 μg/mL
Accession号P02778
应用ELISA
检测方法Colorimetric
实验类型Quantitative
回收率80-120%
运输2-8 ℃
稳定性和存储The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
规格

Eldelumab

别名BMS-936557, MDX-1100, 946414-98-8
背景

C-X-C motif chemokine 10 (Eldelumab) is a ~10 kDa protein. Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site.

1. Romagnani, P. et al. (2001) Blood 97, 601-7. PMID: 11157474
2. Sidahmed, AM. et al. (2012) Cytokine 59, 433-41. PMID: 22652417
3. Angiolillo, AL. et al. (1995) The Journal of experimental medicine 182, 155-62. PMID: 7540647
4. Smit, MJ. et al. (2003) Blood 102, 1959-65. PMID: 12750173
5. Gao, JM. et al. (2009) Acta pharmacologica Sinica 30, 193-201. PMID: 19151743
6. Cheeran, MC. et al. (2003) Journal of virology 77, 4502-15. PMID: 12663757
NoteFor Research Use Only.
图片
参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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