| 靶标 | Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter, 36 kDa nucleolar protein HNP36, ENT2, Equilibrative nucleoside transporter 2, SLC29A2, Hydrophobic nucleolar protein, 36 kDa, Equilibrative NBMPR-insensitive nucleoside transporter, Nucleoside transporter, ei-type, Delayed-early response protein 12, Solute carrier family 29 member 2, HNP36, DER12 |
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| 背景 | Equilibrative nucleoside transporter 2 (ENT2/SLC29A2) is a ~50 kDa protein. Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent, passive transporter. Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine. Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil). Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites. 1. Ward, JL. et al. (2000) The Journal of biological chemistry 275, 8375-81. PMID: 107226692. Mangravite, LM. et al. (2003) American journal of physiology. Renal physiology 284, F902-10. PMID: 125275523. Ward, JL. et al. (2003) Archives of biochemistry and biophysics 411, 19-26. PMID: 125909194. Owen, RP. et al. (2006) Drug metabolism and disposition: the biological fate of chemicals 34, 12-5. PMID: 162148505. Yao, SY. et al. (2011) The Journal of biological chemistry 286, 32552-62. PMID: 217956836. Griffiths, M. et al. (1997) The Biochemical journal 328 ( Pt 3), 739-43. PMID: 93967147. Crawford, CR. et al. (1998) The Journal of biological chemistry 273, 5288-93. PMID: 9478986 |
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