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InVivoMAb Anti-Mouse IL-17A Antibody (BZN035) (MS856010)

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规格：
  • 100ug
  • 1mg
数量：
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概述
货号MS856010
品牌abinScience
描述
InVivoMAb Anti-Mouse IL17A Antibody (BZN035) [BZN035] (MS856010) is a mouse monoclonal antibody detecting CTLA-8 in FCM, Neutralization. Suitable for Mouse.
Highlights
  • ●Flow Cytometry — Validated for flow cytometry applications.
种属反应性Mouse
应用FCM, Neutralization
同种型IgG2a
克隆号BZN035
靶标CTLA-8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL-17A, IL17A, CTLA8, IL-17, Interleukin-17A
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
相关产品 pH 7.4 Dilution Buffer
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q62386
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Interleukin-17A (IL17A) is a ~17 kDa protein. Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. IL17A is the therapeutic target of secukinumab (Cosentyx).

1. Liang, SC. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 7791-9. PMID: 18025225
2. Ishigame, H. et al. (2009) Immunity 30, 108-19. PMID: 19144317
3. Lee, JS. et al. (2015) Immunity 43, 727-38. PMID: 26431948
4. Park, H. et al. (2005) Nature immunology 6, 1133-41. PMID: 16200068
5. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 17911633
6. Chen, K. et al. (2016) Cell host & microbe 20, 596-605. PMID: 27923703
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlMouse IgG2a Recombinant Isotype Control Antibody (S43.10) (MF533307)
图片

  • SDS-PAGE

    SDS-PAGE for InVivoMAb Anti-Mouse IL17A Antibody (BZN035).

  • Bioactivity

    Detects Mouse IL17A in indirect ELISAs.

  • Bioactivity

    SEC-HPLC detection for InVivoMAb Anti-Mouse IL17A Antibody (BZN035).

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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