InVivoMAb Anti-Clostridium botulinum botA/BOTOX Antibody (BNTA-4.1) (JN888020)

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100ug
1mg

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概述

货号	JN888020
品牌	abinScience
描述	InVivoMAb Anti-Clostridium botulinum botA/BoNT Antibody (BNTA-4.1) [BNTA-4.1] (JN888020) is a human monoclonal antibody detecting Botulinum neurotoxin type A in ELISA, Neutralization.
种属反应性	Clostridium botulinum
应用	ELISA, Neutralization
宿主	Human
同种型	IgG1
克隆号	BNTA-4.1
克隆类型	Monoclonal
靶标	Botulinum neurotoxin type A, BoNT/A, Bontoxilysin-A, BOTOX, Botulinum neurotoxin type A1, Botulinum neurotoxin A light chain, LC, 3.4.24.69, Botulinum neurotoxin A heavy chain, HC, botA, atx, bonT
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
相关产品	pH 7.4 Dilution Buffer
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P0DPI0
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Botulinum neurotoxin type A (botA/BoNT) is a ~149 kDa protein. Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin A which has 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins of synaptic vesicles. Receptor proteins are exposed on host presynaptic cell membrane during neurotransmitter release, when the toxin heavy chain (HC) binds to them. Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway. When the pH of the toxin-containing endosome drops a structural rearrangement occurs so that the N-terminus of the HC forms pores that allows the light chain (LC) to translocate into the cytosol. 1. BURGEN, AS. et al. (1949) The Journal of physiology 109, 10-24. PMID: 15394302 2. Zhou, L. et al. (1995) Biochemistry 34, 15175-81. PMID: 7578132 3. Fischer, A. et al. (2007) The Journal of biological chemistry 282, 29604-11. PMID: 17666397 4. Fischer, A. et al. (2008) PLoS pathogens 4, e1000245. PMID: 19096517 5. Yowler, BC. et al. (2002) The Journal of biological chemistry 277, 32815-9. PMID: 12089155 6. Dong, M. et al. (2006) Science (New York, N.Y.) 312, 592-6. PMID: 16543415 7. Mahrhold, S. et al. (2006) FEBS letters 580, 2011-4. PMID: 16545378 8. Dong, M. et al. (2008) Molecular biology of the cell 19, 5226-37. PMID: 18815274
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Clostridium botulinum botA/BoNT Antibody (BNTA-4.1)

参考文献

产品说明书

InVivoMAb Anti-Clostridium botulinum botA/BOTOX Antibody (BNTA-4.1).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

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InVivoMAb Anti-Clostridium botulinum botA/BOTOX Antibody (BNTA-4.1) (JN888020)

概述

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参考文献

产品说明书

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重组蛋白

抗体

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实验相关试剂

InVivoMAb Anti-Clostridium botulinum botA/BOTOX Antibody (BNTA-4.1) (JN888020)

概述

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参考文献

产品说明书

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