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InVivoMAb Anti-Human Dkk-1 Antibody (DKN-01) (HF914010)

价格:
规格：
  • 100ug
  • 1mg
数量：
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概述
货号HF914010
品牌abinScience
描述
InVivoMAb Anti-Human DKK1 Antibody (DKN-01) [DKN-01] (HF914010) is a mouse monoclonal antibody detecting Dickkopf-1 in ELISA, Neutralization. Suitable for Human.
种属反应性Human
应用ELISA, Neutralization
同种型IgG2a, kappa
克隆号DKN-01
靶标Dickkopf-1, SK, hDkk-1, Dkk-1, Dickkopf-related protein 1, DKK1
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号O94907
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Dickkopf-related protein 1 (DKK1) is a ~28 kDa protein. Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity.

1. Ahn, VE. et al. (2011) Developmental cell 21, 862-73. PMID: 22000856
2. Niehrs, C. (2006) Oncogene 25, 7469-81. PMID: 17143291
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlMouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)
图片

  • Bioactivity

    Detects Human DKK1 in indirect ELISAs.

  • SDS-PAGE

    SDS-PAGE for InVivoMAb Anti-Human DKK1 Antibody (DKN-01).

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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