| 货号 | HV681016 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Humanized |
| 同种型 | IgG1-kappa |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | Endosialin, TEM1, CD164L1, Tumor endothelial marker 1, CD248 |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | Q9HCU0 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | MORAb-004, 946415-62-9 |
| 背景 | Ontuxizumab (MORAb-004) is a humanized IgG1/κ anti-endosialin (TEM-1 or CD248) monoclonal antibody with antitumor effects. Ontuxizumab can be used for the research of cancer. • Tumor Endothelial Marker 1 (TEM1/Endosialin/CD248) Enhances Wound Healing by Interacting with Platelet-Derived Growth Factor Receptors., PMID:30986375 • TEM1/endosialin/CD248 promotes pathologic scarring and TGF-β activity through its receptor stability in dermal fibroblasts., PMID:38254097 • Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysm., PMID:39113704 • Role of tumor endothelial marker 1 (Endosialin/CD248) lectin-like domain in lipopolysaccharide-induced macrophage activation and sepsis in mice., PMID:33737161 • Tumor endothelial marker 1 is upregulated in heart after cardiac injury and participates in cardiac remodeling., PMID:35732643 • Preclinical Evaluation and Dosimetry of [111In]CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1)., PMID:31993928 • Tumor endothelial marker 1-specific DNA vaccination targets tumor vasculature., PMID:24642465 • Endosialin: molecular and functional links to tumor angiogenesis., PMID:26774137 • Endosialin (Tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells., PMID:18187565 • Tumour endothelial marker 1/endosialin-mediated targeting of human sarcoma., PMID:29304474 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
SEC-HPLC detection for Research Grade Ontuxizumab.
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