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Anti-Human TRAILR1/TNFRSF10A Reference Antibody (Mapatumumab, RUO) (HT017016)

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概述
货号HT017016
品牌abinScience
描述
Mapatumumab (HT017016) is a research-grade recombinant antibody targeting CD261. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG1-nd
表达系统Mammalian cells
靶标TNF-related apoptosis-inducing ligand receptor 1, APO2, Death receptor 4, TRAIL receptor 1, TRAIL-R1, CD261, DR4, TRAILR1, TNFRSF10A, Tumor necrosis factor receptor superfamily member 10A
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号O00220
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名HGS-ETR1, TRM-1, 658052-09-6
背景

Tumor necrosis factor receptor superfamily member 10A (CD261/TNFRSF10A) is a ~50 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

1. Ramamurthy, V. et al. (2015) Acta crystallographica. Section F, Structural biology communications 71, 1273-81. PMID: 26457518
2. Chyuan, IT. et al. (2024) Journal of biomedical science 31, 33. PMID: 38532423
3. Rossin, A. et al. (2009) The Biochemical journal 419, 185-92, 2 p following 192. PMID: 19090789
4. Chaudhary, PM. et al. (1997) Immunity 7, 821-30. PMID: 9430227
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107)
图片

  • Bioactivity

    SEC-HPLC detection for Research Grade Mapatumumab.

  • SDS-PAGE

    SDS-PAGE for Research Grade Mapatumumab.

  • Western blot

    Western blot analysis was performed using anti-CD261/TNFRSF10A monoclonal antibody at 1ug/mL on various samples.
    Lane 1: recombinant human CD261/TNFRSF10A (Catalog No: HT017011)
    Lane 2: negative control

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human TRAILR1/TNFRSF10A Reference Antibody (Mapatumumab, RUO)

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