ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型
IgG4-kappa
表达系统
Mammalian cells
靶标
T-cell immunoglobulin mucin receptor 3, HAVcr-2, TIMD-3, T-cell membrane protein 3, HAVCR2, Hepatitis A virus cellular receptor 2, CD366, TIMD3, TIM-3, TIM3, T-cell immunoglobulin and mucin domain-containing protein 3
内毒素水平
< 10 EU/mg
纯度
>95% purity as determined by SDS-PAGE.
纯化方式
Protein A/G purified from cell culture supernatant.
Accession号
Q8TDQ0
状态
Liquid
保存溶液
0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
TSR-022, 2022215-65-0
背景
Hepatitis A virus cellular receptor 2 (CD366/TIM-3) is a ~33 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance.
1. Gorman, JV. et al. (2014) Immunologic research 59, 56-65. PMID: 24825777
2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861
3. Sánchez-Fueyo, A. et al. (2003) Nature immunology 4, 1093-101. PMID: 14556005
4. Clayton, KL. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 782-91. PMID: 24337741
5. Tomkowicz, B. et al. (2015) PloS one 10, e0140694. PMID: 26492563
6. Gautron, AS. et al. (2014) European journal of immunology 44, 2703-2711. PMID: 24838857
7. Zhu, C. et al. (2005) Nature immunology 6, 1245-52. PMID: 16286920
8. Leitner, J. et al. (2013) PLoS pathogens 9, e1003253. PMID: 23555261
