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Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO) (HF664016)

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概述
货号HF664016
品牌abinScience
描述
Garadacimab (HF664016) is a research-grade recombinant antibody targeting F12. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG4-lambda
表达系统Mammalian cells
靶标F12, HAF, Hageman factor, Beta-factor XIIa part 2, Coagulation factor XII
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P00748
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名CSL312, 2162134-62-3
背景

Coagulation factor XII (F12/Coagulationfactor XII) is a ~67 kDa protein. Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.

1. Naito, K. et al. (1991) The Journal of biological chemistry 266, 7353-8. PMID: 2019570
2. MacQuarrie, JL. et al. (2011) Blood 117, 4134-41. PMID: 21304106
3. Brunnée, T. et al. (1993) Blood 81, 580-6. PMID: 8427954
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)
图片

  • Bioactivity

    SEC-HPLC detection for Research Grade Garadacimab.

  • SDS-PAGE

    SDS-PAGE for Research Grade Garadacimab

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO)

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