| 货号 | HT343026 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Human |
| 同种型 | IgG4-kappa |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | GDF-8, GDF8, MSTN, Myostatin, Growth/differentiation factor 8 |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | O14793 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | REGN-1033, REGN1033, SAR-391786, 1429201-24-0 |
| 背景 | Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy. • Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction., PMID:33938454 • Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member., PMID:9139826 • GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury., PMID:38019905 • Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells., PMID:25641196 • Growth differentiation factor myostatin regulates epithelial-mesenchymal transition genes and enhances invasion by increasing serine protease inhibitors E1 and E2 in human trophoblast cells., PMID:37738042 • Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation., PMID:27481097 • Circulating Growth Differentiation Factor 11/8 Levels Decline With Age., PMID:26489925 • Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11., PMID:30814254 • Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells., PMID:26607022 • Molecular characterization of latent GDF8 reveals mechanisms of activation., PMID:29348202 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
SEC-HPLC detection for Research Grade Trevogrumab.
SDS-PAGE for Research Grade Trevogrumab.
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