Anti-Human DLL4 Reference Antibody (Enoticumab, RUO) (HV571026)

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概述

货号	HV571026
品牌	abinScience
描述	Enoticumab (HV571026) is a research-grade recombinant antibody targeting Delta-like protein 4. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG1-kappa
表达系统	Mammalian cells
经测试应用	WB
靶标	Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q9NR61
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	REGN-421, SAR153192, 1192578-27-0
背景	Delta-like protein 4 (DLL4) is a ~74 kDa protein. Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. 1. Yoneya, T. et al. (2001) Journal of biochemistry 129, 27-34. PMID: 11134954 2. Brütsch, R. et al. (2010) Circulation research 107, 592-601. PMID: 20616313 3. Del Barrio, MG. et al. (2007) Development (Cambridge, England) 134, 3427-36. PMID: 17728344
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Anti-LASV GPC Recombinant Antibody (Fab 37.7) (VK453013)

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SEC-HPLC

SEC-HPLC detection for Research Grade Enoticumab.
Bioactivity

Detects DLL4 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Enoticumab.
Western blot

Western blot analysis was performed using anti-DLL4 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human DLL4 (Catalog No: HV571011)
Lane 2: negative control

参考文献

产品说明书

Anti-Human DLL4 Reference Antibody (Enoticumab, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human DLL4 Reference Antibody (Enoticumab, RUO) (HV571026)

概述

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参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human DLL4 Reference Antibody (Enoticumab, RUO) (HV571026)

概述

图片

参考文献

产品说明书

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