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Anti-Human Nogo Reference Antibody (Atinumab, RUO) (HP021026)

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概述
货号HP021026
品牌abinScience
描述
Atinumab (HP021026) is a research-grade recombinant antibody targeting RTN-x. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG4-kappa
表达系统Mammalian cells
靶标RTN-x, Reticulon-4, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, NOGO, Nogo protein, Neurite outgrowth inhibitor, NSP, Reticulon-5, KIAA0886, RTN4, Foocen
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q9NQC3
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名6A3-IgG4, ATI355, 1226761-65-4
背景

Reticulon-4 (RTN4) is a ~129 kDa protein. Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities (Probable).

1. Yamamoto, Y. et al. (2014) The Biochemical journal 458, 69-79. PMID: 24262037
2. Urade, T. et al. (2014) The Kobe journal of medical sciences 60, E57-65. PMID: 25612671
3. Wang, S. et al. (2016) eLife 5. PMID: 27619977
4. Rämö, O. et al. (2016) Scientific reports 6, 35969. PMID: 27786289
5. Christodoulou, A. et al. (2016) Journal of cell science 129, 1552-65. PMID: 26906412
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)
Human IgG4 (S228P & L235E) Recombinant Isotype Control Antibody (HyHEL-10) (HP614107)
Human IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)
图片

  • SEC-HPLC

    SEC-HPLC detection for Research Grade Atinumab.

  • Bioactivity

    Detects Reticulon-4/RTN4 in indirect ELISAs.

  • SDS-PAGE

    SDS-PAGE for Anti-Human Nogo Reference Antibody (Atinumab, RUO)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human Nogo Reference Antibody (Atinumab, RUO)

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