ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型
IgG1-kappa
表达系统
Mammalian cells
靶标
SLC39A6, LIV1, Zrt- and Irt-like protein 6, Zinc transporter ZIP6, ZIP-6, Estrogen-regulated protein LIV-1, Solute carrier family 39 member 6, ZIP6
内毒素水平
< 10 EU/mg
纯度
>95% purity as determined by SDS-PAGE.
纯化方式
Protein A/G purified from cell culture supernatant.
Accession号
Q13433
状态
Liquid
保存溶液
0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
hLIV22, SGN-LIV1A, 1629760-28-6
背景
Zinc transporter ZIP6 (SLC39A6/LIV-1) is a ~85 kDa protein. Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis.
1. Taylor, KM. et al. (2003) The Biochemical journal 375, 51-9. PMID: 12839489
2. Chowanadisai, W. et al. (2008) Brain research 1199, 10-9. PMID: 18272141
3. Yu, M. et al. (2011) The Journal of experimental medicine 208, 775-85. PMID: 21422171
4. Hogstrand, C. et al. (2013) The Biochemical journal 455, 229-37. PMID: 23919497
5. Taylor, KM. et al. (2016) The Biochemical journal 473, 2531-44. PMID: 27274087
6. Kim, B. et al. (2021) Frontiers in immunology 12, 687367. PMID: 34394081
7. Nimmanon, T. et al. (2021) Cellular and molecular life sciences : CMLS 78, 1781-1798. PMID: 32797246
Note
For research use only. Not suitable for clinical or therapeutic use.
