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Anti-Human LOXL2 Reference Antibody (Simtuzumab, RUO) (HP610016)

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概述
货号HP610016
品牌abinScience
描述
Simtuzumab (HP610016) is a research-grade recombinant antibody targeting LOXL2. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG4-kappa
表达系统Mammalian cells
靶标LOXL2, Lysyl oxidase-related protein WS9-14, Lysyl oxidase homolog 2, Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q9Y4K0
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名AB0024, GS-6624, 1318075-13-6
背景

Lysyl oxidase homolog 2 (LOXL2) is a ~86 kDa protein. Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2.

1. Herranz, N. et al. (2016) The FEBS journal 283, 4263-4273. PMID: 27735137
2. Iturbide, A. et al. (2015) Molecular cell 58, 755-66. PMID: 25959397
3. Peinado, H. et al. (2005) The EMBO journal 24, 3446-58. PMID: 16096638
4. Cuevas, EP. et al. (2014) Biology open 3, 129-37. PMID: 24414204
5. Millanes-Romero, A. et al. (2013) Molecular cell 52, 746-57. PMID: 24239292
6. Cuevas, EP. et al. (2017) Scientific reports 7, 44988. PMID: 28332555
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)
图片

  • SEC-HPLC

    SEC-HPLC detection for Research Grade Simtuzumab.

  • Bioactivity

    Detects LOXL2 in indirect ELISAs.

  • SDS-PAGE

    SDS-PAGE for Research Grade Simtuzumab

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human LOXL2 Reference Antibody (Simtuzumab, RUO)

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