| 货号 | HV162016 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Human |
| 同种型 | IgG2-lambda |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | FzE1, Frizzled-1, hFz1, Fz-1, FZD1 |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | Q9UP38 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | OMP-18R5, 1345009-45-1 |
| 背景 | Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody. Vantictumab inhibits Wnt pathway signaling by binding to FZD1/2/5/7/8 receptors. Vantictumab can be studied against cancers through direct actions on tumor cells, including CSCs, and effects on the stroma, such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma. • Knockdown of the Wnt receptor Frizzled-1 (FZD1) reduces MDR1/P-glycoprotein expression in multidrug resistant leukemic cells and inhibits leukemic cell proliferation., PMID:29482174 • The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway., PMID:14739301 • Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway., PMID:22484497 • Functional and association analysis of frizzled 1 (FZD1) promoter haplotypes with femoral neck geometry., PMID:20051274 • Functional characterization of genetic variation in the Frizzled 1 (FZD1) promoter and association with bone phenotypes: more to the LRP5 story?, PMID:18715140 • Transcriptional Regulation of Frizzled-1 in Human Osteoblasts by Sp1., PMID:27695039 • Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response., PMID:10557084 • Oligodendroglial ring finger protein Rnf43 is an essential injury-specific regulator of oligodendrocyte maturation., PMID:34390652 • miR-135b reverses chemoresistance of non-small cell lung cancer cells by downregulation of FZD1., PMID:27643554 • FZD1 activates protein kinase C delta-mediated drug-resistance in multidrug-resistant MES-SA/Dx5 cancer cells., PMID:24814288 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Vantictumab.
SEC-HPLC detection for Research Grade Vantictumab.
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