Anti-Human Frizzled-1 Reference Antibody (Vantictumab, RUO) (HV162016)

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概述
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概述

货号	HV162016
品牌	abinScience
描述	Vantictumab (HV162016) is a research-grade recombinant antibody targeting FzE1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主	Human
同种型	IgG2-lambda
表达系统	Mammalian cells
克隆类型	Monoclonal
靶标	FzE1, Frizzled-1, hFz1, Fz-1, FZD1
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q9UP38
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	OMP-18R5, 1345009-45-1
背景	Frizzled-1 (FZD1) is a ~71 kDa protein. Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B. Contradictory results showing activation by WNT7B have been described for mouse. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. 1. Gazit, A. et al. (1999) Oncogene 18, 5959-66. PMID: 10557084
Note	For research use only. Not suitable for clinical or therapeutic use.

图片

SDS-PAGE

SDS-PAGE for Research Grade Vantictumab.
Bioactivity

SEC-HPLC detection for Research Grade Vantictumab.
Western blot

Western blot analysis was performed using anti-FZD7 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human FZD7 (Catalog No: HF587011)
Lane 2: negative control

参考文献

产品说明书

Anti-Human Frizzled-1 Reference Antibody (Vantictumab, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

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Anti-Human Frizzled-1 Reference Antibody (Vantictumab, RUO) (HV162016)

概述

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参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Frizzled-1 Reference Antibody (Vantictumab, RUO) (HV162016)

概述

图片

参考文献

产品说明书

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