Anti-Pseudomonas aeruginosa PcrV & Psl Bispecific Reference Antibody (Gremubamab, RUO) (JN076016)

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概述

货号	JN076016
品牌	abinScience
描述	Gremubamab (JN076016) is a research-grade recombinant antibody targeting PcrV & Psl. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Pseudomonas aeruginosa
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主	Human
同种型	VH-CH1-VH-V-KAPPA-CH2-CH3
表达系统	Mammalian cells
克隆类型	Monoclonal
靶标	PcrV & Psl
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	O30527
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	Bispecific, MEDI3902, CAS: 1800381-36-5
背景	Gremubamab (MEDI3902) is a humanized IgG1 kappa anti-PcrV/Psl monoclonal antibody. Gremubamab binds to the PA PcrV protein and Psl exopolysaccharide. Gremubamab has the potential for the research of pseudomonas aeruginosa infections. • A Bispecific Monoclonal Antibody Targeting Psl and PcrV Enhances Neutrophil-Mediated Killing of Pseudomonas aeruginosa in Patients with Bronchiectasis., PMID:38754132 • Pseudomonas aeruginosa PcrV and Psl, the Molecular Targets of Bispecific Antibody MEDI3902, Are Conserved Among Diverse Global Clinical Isolates., PMID:30016475 • Pseudomonas aeruginosa Bacteremic Patients Exhibit Nonprotective Antibody Titers Against Therapeutic Antibody Targets PcrV and Psl Exopolysaccharide., PMID:26333940 • Phase 1 study of MEDI3902, an investigational anti-Pseudomonas aeruginosa PcrV and Psl bispecific human monoclonal antibody, in healthy adults., PMID:30107283 • AAV-vectored expression of monospecific or bispecific monoclonal antibodies protects mice from lethal Pseudomonas aeruginosa pneumonia., PMID:38678160 • Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature., PMID:28463232 • Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models., PMID:31160288 • Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets., PMID:30185667 • Multifunctional Monoclonal Antibody Targeting Pseudomonas aeruginosa Keratitis in Mice., PMID:33147726 • Antivirulence Bispecific Monoclonal Antibody-Mediated Protection against Pseudomonas aeruginosa Ventilator-Associated Pneumonia in a Rabbit Model., PMID:34902264
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects PcrV in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Gremubamab

参考文献

产品说明书

Anti-Pseudomonas aeruginosa PcrV & Psl Bispecific Reference Antibody (Gremubamab, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

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Anti-Pseudomonas aeruginosa PcrV & Psl Bispecific Reference Antibody (Gremubamab, RUO) (JN076016)

概述

图片

参考文献

产品说明书

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重组蛋白

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实验相关试剂

Anti-Pseudomonas aeruginosa PcrV & Psl Bispecific Reference Antibody (Gremubamab, RUO) (JN076016)

概述

图片

参考文献

产品说明书

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