| 货号 | VK705016 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human cytomegalovirus (HCMV/HHV-5) |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Human |
| 同种型 | IgG1, kappa |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | Envelope glycoprotein H, gH, gH, UL75 |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | P12824 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | EV27, MSL109, SDZMSL109, 138660-96-5 |
| 背景 | Sevirumab (MSL-109) is a human IgG1 neutralizing monoclonal antibody against cytomegalovirus (CMV). Sevirumab recognizes CMV gH complexes and inhibits CMV replication with an EC50 of 0.3 μg/mL. • Characterization of the human cytomegalovirus UL75 (glycoprotein H) late gene promoter., PMID:12490392 • Viral shedding, and distribution of cytomegalovirus glycoprotein H (UL75), glycoprotein B (UL55), and glycoprotein N (UL73) genotypes in congenital cytomegalovirus infection., PMID:32086150 • Human cytomegalovirus envelope glycoprotein B, H, and N polymorphisms among infants of Shanghai area in China., PMID:32567060 • Cytomegalovirus glycoprotein H genotype distribution and the relationship with hearing loss in children., PMID:24615599 • The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection., PMID:9188570 • Cytomegalovirus Genetic Diversity Following Primary Infection., PMID:31593588 • Glycoprotein H of human cytomegalovirus (HCMV) forms a stable complex with the HCMV UL115 gene product., PMID:1328481 • Distribution of the CMV glycoprotein gH/gL/gO and gH/gL/pUL128/pUL130/pUL131A complex variants and associated clinical manifestations in infants infected congenitally or postnatally., PMID:31705022 • Characterization of a novel third member of the human cytomegalovirus glycoprotein H-glycoprotein L complex., PMID:9188610 • Expression and reconstitution of the gH/gL/gO complex of human cytomegalovirus., PMID:12361760 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
SEC-HPLC detection for Research Grade Sevirumab.
SDS-PAGE for Research Grade Sevirumab.
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