| 货号 | VK515016 |
|---|---|
| 品牌 | abinScience |
| 描述 | Diridavumab, the alternative name, CR6261, is a human monoclonal antibody directed against influenza A hemagglutinin. The CR6261 antibody was first discovered by the Scripps Institute and Crucell, a Dutch biopharmaceutical company, and later developed by Janssen Pharmaceutical Companies of Johnson & Johnson under the trade name diridavumab. Cr6261 is under investigation in clinical trial NCT02016066 (A Study to Assess the Safety, Pharmacokinetics and Immunogenicity of Diridavumab in Japanese Healthy Participants). |
| 种属反应性 | Influenza A virus |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Human |
| 同种型 | IgG1, lambda |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | HA/Hemagglutinin |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | P03455 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | CR-6261, CR6261, 1393659-46-5 |
| 背景 | HY-P990944 is an influenza A virus hemagglutinin HA-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001). • A soluble domain of the membrane-anchoring chain of influenza virus hemagglutinin (HA2) folds in Escherichia coli into the low-pH-induced conformation., PMID:8618870 • Recognition of influenza virus hemagglutinin by subtype-specific and cross-reactive proliferative T cells: contribution of HA1 and HA2 polypeptide chains., PMID:3871116 • Molecular mechanisms of the influenza fusion peptide: insights from experimental and simulation studies., PMID:34710289 • Anti-hemagglutinin monomeric nanobody provides prophylactic immunity against H1 subtype influenza A viruses., PMID:38985719 • Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH., PMID:35939703 • A monoclonal antibody specific to the HA2 glycoprotein of influenza A virus hemagglutinin that inhibits its fusion activity reduces replication of the virus., PMID:15068378 • Structural studies on membrane-embedded influenza hemagglutinin and its fragments., PMID:9300499 • Charged N-terminus of Influenza Fusion Peptide Facilitates Membrane Fusion., PMID:29443945 • Is virulence of H5N2 influenza viruses in chickens associated with loss of carbohydrate from the hemagglutinin?, PMID:6516214 • Molecular composition of the 16S toxin produced by a Clostridium botulinum type D strain, 1873., PMID:9802560 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
SEC-HPLC detection for Research Grade Diridavumab.
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