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Anti-Human PD-1 Reference Antibody (Nivolumab, RUO) (HS870096)

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概述
货号HS870096
品牌abinScience
描述
Nivolumab (HS870096) is a research-grade recombinant antibody targeting CD1. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG4-kappa
表达系统Mammalian cells
靶标Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q15116
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名BMS-936558, MDX-1106, ONO-4538, CAS: 946414-94-4, Opdivo
背景

Programmed cell death protein 1 (CD279/PD-1) is a ~31 kDa protein. Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with TCR-CD3 in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. CD279 is the therapeutic target of pembrolizumab (Keytruda) and nivolumab (Opdivo).

1. Fife, BT. et al. (2011) Annals of the New York Academy of Sciences 1217, 45-59. PMID: 21276005
2. Bardhan, K. et al. (2019) Scientific reports 9, 17252. PMID: 31754127
3. Patsoukis, N. et al. (2020) Communications biology 3, 128. PMID: 32184441
4. Xiao, X. et al. (2023) Nature communications 14, 2859. PMID: 37208329
5. Zak, KM. et al. (2015) Structure (London, England : 1993) 23, 2341-2348. PMID: 26602187
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG4 (S228P & L235E) Recombinant Isotype Control Antibody (HyHEL-10) (HP614107)
图片

  • SEC-HPLC

    SEC-HPLC detection for Research Grade Nivolumab.

  • Bioactivity

    Detects Human CD279/PDCD1/PD1 in indirect ELISAs.

  • SDS-PAGE

    SDS-PAGE for Research Grade Nivolumab

  • Bioactivity

    Detected by Anti-Nivolumab Non-Neutralizing Antibody (SAA2348) (Catalog No: AS870033) in indirect ELISA

  • Bioactivity

    Detected by Anti-Nivolumab Non-Neutralizing Antibody (SAA2349) (Catalog No: AS870043) in indirect ELISA

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human PD-1 Reference Antibody (Nivolumab, RUO)

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