| 货号 | HX243016 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Humanized |
| 同种型 | IgG1-kappa |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | IL-5R subunit alpha, IL-5 receptor subunit alpha, IL5RA, IL-5RA, IL-5R-alpha, Interleukin-5 receptor subunit alpha, CDw125, CD125, IL5R |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | Q01344 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | BIW-8405, KHK4563, MEDI-563, 1044511-01-4 |
| 背景 | Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma. • Benralizumab for the treatment of asthma., PMID:29517082 • Eosinophils, the IL-5/IL-5Rα axis, and the biologic effects of benralizumab in severe asthma., PMID:31734469 • Serum Concentration of IL-5 Receptor (IL-5R) and Associations with Disease Severity in Patients with Chronic Spontaneous Urticaria (CSU) and Atopic Dermatitis (AD)., PMID:39062845 • A genetic effect of IL-5 receptor α polymorphism in patients with aspirin-exacerbated respiratory disease., PMID:23470716 • IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans., PMID:17620072 • Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output., PMID:19654410 • IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils., PMID:26276876 • Cord blood molecular biomarkers of eosinophilopoiesis: kinetic analysis of GATA-1, MBP1 and IL-5R alpha mRNA expression., PMID:20337967 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Benralizumab.
SEC-HPLC detection for Research Grade Benralizumab.
Detects Human CD125/IL5RA in indirect ELISAs.
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