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Anti-Human ICOS Reference Antibody (Alomfilimab, RUO) (HV702036)

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概述
货号HV702036
品牌abinScience
描述
Alomfilimab (HV702036) is a research-grade recombinant antibody targeting CD278. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG1-Kappa
表达系统Mammalian cells
靶标CD278, ICOS, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, AILIM
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q9Y6W8
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名399F05, KY-1044, KY1044, STIM003, 2378692-24-9
背景

Inducible T-cell costimulator (CD278/ICOS) is a ~22 kDa protein. Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection. Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling. In addition, activates PI3K signaling pathways independently of calcium flux.

1. Hutloff, A. et al. (1999) Nature 397, 263-6. PMID: 9930702
2. Rujas, E. et al. (2020) Nature communications 11, 5066. PMID: 33033255
3. Pedros, C. et al. (2016) Nature immunology 17, 825-33. PMID: 27135603
4. Wan, Z. et al. (2020) Cellular & molecular immunology 17, 143-152. PMID: 30523347
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)
图片

  • SDS-PAGE

    SDS-PAGE for Research Grade Alomfilimab

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human ICOS Reference Antibody (Alomfilimab, RUO)

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