| 货号 | HV066016 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Human |
| 同种型 | IgG1-Kappa |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | Neurotensin receptor 3, Gp95, Glycoprotein 95, Sortilin, 100 kDa NT receptor, NTR3, SORT1, NT3 |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | Q99523 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | AL001, 2376132-27-1 |
| 背景 | Latozinemab (AL001) is a recombinant human anti-Sortilin monoclonal antibody. Latozinemab effectively binds Sortilin with a high affinity and blocks the interaction between progranulin protein (PGRN) and Sortilin receptor. Latozinemab has the potential for progranulin gene (GRN) mutations causative of Frontotemporal dementia (FTD) (FTD-GRN) research. • The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor., PMID:9756851 • Sortilin is dispensable for secondary injury processes following traumatic brain injury in mice., PMID:39170542 • Neurotrophins and their involvement in digestive cancers., PMID:30741921 • Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury., PMID:35634462 • Peptides other than the neurotrophins that can be cleaved from proneurotrophins: a neglected story., PMID:17917853 • The Neurotrophin Receptor TrkC as a Novel Molecular Target of the Antineuroblastoma Action of Valproic Acid., PMID:34360553 • Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons., PMID:21261755 • Neurotrophins and their receptors in early development of the mammalian nervous system., PMID:21196952 • Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing., PMID:19940174 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
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