Anti-Human Angiopoietin-2 Reference Antibody (Zansecimab, RUO) (HT073046)

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概述

货号	HT073046
品牌	abinScience
描述	Zansecimab (HT073046) is a research-grade recombinant antibody targeting ANG-2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主	Human
同种型	IgG4-Kappa
表达系统	Mammalian cells
克隆类型	Monoclonal
靶标	ANG-2, ANGPT2, Angiopoietin-2
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	O15123
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	LY-3127804, LY3127804, 2415205-37-5
背景	Angiopoietin-2 (ANGPT2/ANG-2) is a ~56 kDa protein. Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis. 1. Lee, HJ. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1200-8. PMID: 15284220 2. Yacyshyn, OK. et al. (2009) Angiogenesis 12, 25-33. PMID: 19116766 3. Yuan, HT. et al. (2009) Molecular and cellular biology 29, 2011-22. PMID: 19223473 4. Maisonpierre, PC. et al. (1997) Science (New York, N.Y.) 277, 55-60. PMID: 9204896 5. Leppänen, VM. et al. (2020) Science translational medicine 12. PMID: 32908006
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Zansecimab

参考文献

产品说明书

Anti-Human Angiopoietin-2 Reference Antibody (Zansecimab, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Angiopoietin-2 Reference Antibody (Zansecimab, RUO) (HT073046)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Angiopoietin-2 Reference Antibody (Zansecimab, RUO) (HT073046)

概述

图片

参考文献

产品说明书

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