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Anti-Human MUC17/MUC3 & CD3 epsilon Bispecific Reference Antibody (Vepsitamab, RUO) (HV684016)

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概述
货号HV684016
品牌abinScience
描述
Vepsitamab (HV684016) is a research-grade recombinant antibody targeting CD3. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型(scFv-heavy-lambda)-(scFv-heavy-lambda)-scFc
表达系统Mammalian cells
靶标MUC-3, MUC-17, MUC17, Small intestinal mucin-3, Mucin-17, MUC3, T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T-cell surface glycoprotein CD3 epsilon chain
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q685J3 & P07766
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名Bispecific, AMG199, AMG-199, AMG1992413453-53-7
背景Vepsitamab (AMG 199) is an anti-MUC17/CD3 BiTE antibody that binds to CD3 on T cells and MUC17 expressed on tumor cells, mediates redirected tumor cell lysis, and induces T cell activation and proliferation.
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)
Human IgG1 (E356D/M358L), kappa Recombinant Isotype Control Antibody (HyHEL-10) (HV080013)
Anti-LASV GPC Recombinant Antibody (Fab 37.7) (VK453013)
图片

  • Bioactivity

    Detects Recombinant Human MUC17 Protein, N-His (Cat No.: HV684012) in indirect ELISA.

  • Western blot

    Western blot analysis was performed using anti-human MUC17 monoclonal antibody at 1ug/mL on various samples.
    Lane 1: recombinant human MUC17 (Catalog No: HV684012)
    Lane 2: negative control

  • SDS-PAGE

    SDS-PAGE for Research Grade Vepsitamab

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human MUC17/MUC3 & CD3 epsilon Bispecific Reference Antibody (Vepsitamab, RUO)

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