| 货号 | HC517016 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Human |
| 同种型 | IgG1-kappa |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | IFN-gamma-inducing factor, IL1F4, Interleukin-1 gamma, IL-18, IL-1 gamma, Interleukin-18, Interferon gamma-inducing factor, IGIF, IL18, Iboctadekin |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | Q14116 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 背景 | Camoteskimab (AVTX-007) is an anti-IL-18 monoclonal antibody with fully humanized, high-affinity. Camoteskimab is promising for research of cardiovascular diseases and autoinflammatory diseases, including adult-onset Still’s disease (AOSD) and multiple myeloma. • Mechanism and Regulation of NLRP3 Inflammasome Activation., PMID:27669650 • Inflammasomes in neuroinflammatory and neurodegenerative diseases., PMID:31015277 • IL-27 enhances IL-15/IL-18-mediated activation of human natural killer cells., PMID:31277710 • Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18., PMID:28954221 • NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis., PMID:29880500 • Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases., PMID:31874111 • ACSL6-activated IL-18R1-NF-κB promotes IL-18-mediated tumor immune evasion and tumor progression., PMID:39292786 • Pretreatment with IL-15 and IL-18 rescues natural killer cells from granzyme B-mediated apoptosis after cryopreservation., PMID:38729924 • Interleukin-18 and COVID-19., PMID:34911594 • Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth., PMID:39891018 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
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