ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型
IgG4, kappa
表达系统
Mammalian cells
靶标
CD85 antigen-like family member D, Monocyte/macrophage immunoglobulin-like receptor 10, MIR-10, ILT4, LIR-2, ILT-4, Immunoglobulin-like transcript 4, MIR10, CD85d, Leukocyte immunoglobulin-like receptor subfamily B member 2, Leukocyte immunoglobulin-like receptor 2, LIR2, LILRB2
内毒素水平
< 10 EU/mg
纯度
>95% purity as determined by SDS-PAGE.
纯化方式
Protein A/G purified from cell culture supernatant.
Accession号
Q8N423
状态
Liquid
保存溶液
0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Leukocyte immunoglobulin-like receptor subfamily B member 2 (CD85d/LILRB2) is a ~65 kDa protein. Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens.
1. Lepin, EJ. et al. (2000) European journal of immunology 30, 3552-61. PMID: 11169396
2. Shiroishi, M. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 8856-61. PMID: 12853576
3. Shiroishi, M. et al. (2006) The Journal of biological chemistry 281, 10439-47. PMID: 16455647
4. Gregori, S. et al. (2010) Blood 116, 935-44. PMID: 20448110
5. Köstlin, N. et al. (2017) European journal of immunology 47, 374-384. PMID: 27859042
6. Chang, CC. et al. (2002) Nature immunology 3, 237-43. PMID: 11875462
8. Fanger, NA. et al. (1998) European journal of immunology 28, 3423-34. PMID: 9842885
Note
For research use only. Not suitable for clinical or therapeutic use.
