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Research Grade Rilonacept (HF943036)

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概述
货号HF943036
品牌abinScience
描述
Rilonacept (HF943036) is a research-grade recombinant antibody targeting Interleukin-1 beta. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Functional assay, Research in vivo
宿主Human
同种型Fusion - [IL1RAP (interleukin-1 receptor accessory protein) - IL1R1 (type 1 interleukin-1 receptor, interleukin 1 receptor, type I)]2 - IGHG1 Fc (Fragment constant)
表达系统Mammalian cells
靶标Interleukin-1 beta, IL1B, Catabolin, IL1F2, IL-1 beta
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P01584
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名501081-76-1
背景

Interleukin-1 beta (IL1B/IL1F2) is a ~30 kDa protein. Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. IL1B is the therapeutic target of canakinumab (Ilaris).

1. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850
2. Nakahara, H. et al. (2003) Arthritis and rheumatism 48, 1521-9. PMID: 12794819
3. LaRock, CN. et al. (2016) Science immunology 1. PMID: 28331908
4. Van Damme, J. et al. (1985) Nature 314, 266-8. PMID: 3920526
5. Tian, XX. et al. (2021) International endodontic journal 54, 916-925. PMID: 33377178
6. Xia, S. et al. (2021) Nature 593, 607-611. PMID: 33883744
NoteFor research use only. Not suitable for clinical or therapeutic use.
图片

  • Bioactivity

    Detects IL1B/IL1F2 in indirect ELISAs.

  • SDS-PAGE

    SDS-PAGE for Research Grade Rilonacept

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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