Anti-Canine beta-NGF Reference Antibody (Ranevetmab, RUO) (CF909026)

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100ug
1mg
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概述
图片
参考文献
产品说明书

概述

货号

CF909026

品牌

abinScience

描述

Ranevetmab (CF909026) is a research-grade recombinant antibody targeting NGF/Beta-NGF. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

种属反应性

Canine

应用

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

宿主

Canine

同种型

IgG1, kappa

表达系统

Mammalian cells

克隆类型

Monoclonal

经测试应用

靶标

NGF/Beta-NGF

内毒素水平

< 10 EU/mg

纯度

>95% purity as determined by SDS-PAGE.

纯化方式

Protein A/G purified from cell culture supernatant.

Accession号

F1PDQ3

状态

Liquid

保存溶液

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

别名

NV-01, 1632282-27-9

背景

Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs.
• Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair., PMID:37284244
• New insights of the role of β-NGF in the ovulation mechanism of induced ovulating species., PMID:30763273
• Effect of the Camelid's Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis., PMID:28713816
• β-NGF and β-NGF receptor upregulation in blood and synovial fluid in osteoarthritis., PMID:28253191
• The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19., PMID:35095908
• HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy., PMID:38646645
• Heterologous beta-nerve growth factor (β-NGF) given at the LH surge enhances luteal function in dairy heifers., PMID:34186420
• β-NGF Stimulates Steroidogenic Enzyme and VEGFA Gene Expression, and Progesterone Secretion via ERK 1/2 Pathway in Primary Culture of Llama Granulosa Cells., PMID:33195615
• Ovulation mechanism in South American Camelids: The active role of β-NGF as the chemical signal eliciting ovulation in llamas and alpacas., PMID:32088046
• Astragaloside‑IV modulates NGF‑induced osteoblast differentiation via the GSK3β/β‑catenin signalling pathway., PMID:33179111

Note

For research use only. Not suitable for clinical or therapeutic use.

图片

Bioactivity

Detects Canine NGF in indirect ELISA.
SDS-PAGE

SDS-PAGE for Anti-Human beta-NGF Reference Antibody (Ranevetmab, RUO)
Western blot

Western blot analysis was performed using anti-dog NGF monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant dog NGF (Catalog No: CF909011)
Lane 2: negative control

参考文献

产品说明书

Anti-Canine beta-NGF Reference Antibody (Ranevetmab, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Canine beta-NGF Reference Antibody (Ranevetmab, RUO) (CF909026)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Canine beta-NGF Reference Antibody (Ranevetmab, RUO) (CF909026)

概述

图片

参考文献

产品说明书

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