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Anti-Human Complement C2 Reference Antibody (Empasiprubart, RUO) (HY106016)

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概述
货号HY106016
品牌abinScience
描述
Empasiprubart (HY106016) is a research-grade recombinant antibody targeting Complement C2. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG1-kappa
表达系统Mammalian cells
靶标Complement C2, C2, C3/C5 convertase
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P06681
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名2579031-19-7
背景

Complement C2 is a ~83 kDa protein. Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Component C2 is part of the classical, lectin and GZMK complement systems.

1. Rawal, N. et al. (2003) The Journal of biological chemistry 278, 38476-83. PMID: 12878586
2. Milder, FJ. et al. (2006) Structure (London, England : 1993) 14, 1587-97. PMID: 17027507
3. Rawal, N. et al. (2008) The Journal of biological chemistry 283, 7853-63. PMID: 18204047
4. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456
5. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882
6. Héja, D. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 10498-503. PMID: 22691502
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107)
图片

  • SDS-PAGE

    SDS-PAGE for Research Grade Empasiprubart

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human Complement C2 Reference Antibody (Empasiprubart, RUO)

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