| 货号 | HF869016 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Functional assay, Research in vivo |
| 同种型 | Fusion - [ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2 - IGHG1 Fc (Fragment constant) |
| 表达系统 | Mammalian Cells |
| 靶标 | GDF11, BMP-11, BMP11, Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11 |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | O95390 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | ACE-536, luspatercept–aamt, 1373715-00-4 |
| 背景 | Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia. • GDF11: An emerging therapeutic target for liver diseases and fibrosis., PMID:38494851 • Neonatal Systemic AAV-Mediated Gene Delivery of GDF11 Inhibits Skeletal Muscle Growth., PMID:29503194 • GDF11/BMP11 activates both smad1/5/8 and smad2/3 signals but shows no significant effect on proliferation and migration of human umbilical vein endothelial cells., PMID:26919250 • GDF11 rapidly increases lipid accumulation in liver cancer cells through ALK5-dependent signaling., PMID:33684566 • Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11., PMID:10391213 • Induction of reparative dentin formation by ultrasound-mediated gene delivery of growth/differentiation factor 11., PMID:12718768 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
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