Anti-Human IL-1 beta/IL-1F2 Reference Antibody (LY2189102, RUO) (HF943076)

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货号	HF943076
品牌	abinScience
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG
克隆号	LY2189102
表达系统	Mammalian cells
经测试应用	WB
靶标	Interleukin-1 beta, IL1B, Catabolin, IL1F2, IL-1 beta
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P01584
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	LY2189102
背景	Interleukin-1 beta (IL1B/IL1F2) is a ~30 kDa protein. Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. IL1B is the therapeutic target of canakinumab (Ilaris). 1. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850 2. Nakahara, H. et al. (2003) Arthritis and rheumatism 48, 1521-9. PMID: 12794819 3. LaRock, CN. et al. (2016) Science immunology 1. PMID: 28331908 4. Van Damme, J. et al. (1985) Nature 314, 266-8. PMID: 3920526 5. Tian, XX. et al. (2021) International endodontic journal 54, 916-925. PMID: 33377178 6. Xia, S. et al. (2021) Nature 593, 607-611. PMID: 33883744
文献	1. Sloan-Lancaster J, et al. Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1β antibody, in patients with type 2 diabetes. Diabetes Care. 2013 Aug;36(8):2239-46. [HF943076]
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Western blot

Western blot analysis was performed using anti-human IL1B monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human IL1B (Catalog No: HF943012)
Lane 2: negative control
Bioactivity

Detects recombinant human IL1B/IL1F2 (Catalog No: HF943012) in indirect ELISA

产品说明书

Anti-Human IL-1 beta/IL-1F2 Reference Antibody (LY2189102, RUO).pdf

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Anti-Human IL-1 beta/IL-1F2 Reference Antibody (LY2189102, RUO) (HF943076)

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参考文献

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实验相关试剂

Anti-Human IL-1 beta/IL-1F2 Reference Antibody (LY2189102, RUO) (HF943076)

概述

图片

参考文献

产品说明书

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