Anti-Human Integrin beta 6 Reference Antibody (SGN-B6A, RUO) (HB251016)

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概述

货号	HB251016
品牌	abinScience
描述	Anti-Human ITGB6 (SGN-B6A) (HB251016) is a research-grade recombinant antibody targeting ITGB6. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG1-kappa
克隆号	SGN-B6A
表达系统	Mammalian cells
靶标	ITGB6, Integrin beta-6
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P18564
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	SGN-B6A, SGNB6A, SGNB6A
背景	Integrin beta-6 (ITGB6) is a ~85 kDa protein. Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation. 1. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881 2. Ramsay, AG. et al. (2007) Cancer research 67, 5275-84. PMID: 17545607 3. Annes, JP. et al. (2004) The Journal of cell biology 165, 723-34. PMID: 15184403 4. Wang, R. et al. (2012) Molecular biology of the cell 23, 1129-39. PMID: 22278742 5. Dong, X. et al. (2017) Nature 542, 55-59. PMID: 28117447
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human ITGB6 (SGN-B6A).

参考文献

产品说明书

Anti-Human Integrin beta 6 Reference Antibody (SGN-B6A, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Integrin beta 6 Reference Antibody (SGN-B6A, RUO) (HB251016)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Integrin beta 6 Reference Antibody (SGN-B6A, RUO) (HB251016)

概述

图片

参考文献

产品说明书

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