Anti-Human PRAME Reference Antibody (GSK 2302032A, RUO) (HX996016)

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概述

货号	HX996016
品牌	abinScience
描述	Anti-Human PRAME (GSK 2302032A) (HX996016) is a research-grade recombinant antibody targeting Opa-interacting protein 4. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主	Human
同种型	IgG
克隆号	GSK 2302032A
表达系统	Mammalian cells
克隆类型	Monoclonal
靶标	Opa-interacting protein 4, Preferentially expressed antigen of melanoma, MAPE, OIP-4, Melanoma antigen preferentially expressed in tumors, PRAME, OIP4
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P78395
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	GSK-2302032A, GSK2302032A, GSK2302032A
背景	Melanoma antigen preferentially expressed in tumors (PRAME) is a ~57 kDa protein. Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation. Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. 1. Costessi, A. et al. (2011) The EMBO journal 30, 3786-98. PMID: 21822215 2. Lin, HC. et al. (2015) Science (New York, N.Y.) 349, 91-5. PMID: 26138980 3. Epping, MT. et al. (2005) Cell 122, 835-47. PMID: 16179254
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human PRAME (GSK 2302032A)

参考文献

产品说明书

Anti-Human PRAME Reference Antibody (GSK 2302032A, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PRAME Reference Antibody (GSK 2302032A, RUO) (HX996016)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PRAME Reference Antibody (GSK 2302032A, RUO) (HX996016)

概述

图片

参考文献

产品说明书

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