| 背景 | Teriparatide is a portion of human parathyroid hormone (PTH), amino acid sequence 1 through 34, of the complete molecule (containing 84 amino acids). Endogenous PTH is the primary regulator of calcium and phosphate metabolism in bone and kidney. PTH increases serum calcium, partially accomplishing this by increasing bone resorption. Thus, chronically elevated PTH will deplete bone stores. However, intermittent exposure to PTH will activate osteoblasts more than osteoclasts. Thus, once-daily injections of teriparatide have a net effect of stimulating new bone formation leading to increased bone mineral density.
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• Parathyroid hormone and its related peptides in bone metabolism., PMID:34224692
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• Parathyroid hormone (PTH) regulation of metabolic homeostasis: An old dog teaches us new tricks., PMID:35338013
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• MicroRNAs in parathyroid physiopathology., PMID:27816765
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• Parathyroid hormone treatment partially reverses endplate remodeling and attenuates low back pain in animal models of spine degeneration., PMID:37967203
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• PTH and cardiovascular risk., PMID:32192791
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• Parathyromatosis., PMID:23128122
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• Hypoparathyroidism and pseudohypoparathyroidism., PMID:17117292
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• Structural pharmacology of PTH and PTHrP., PMID:35953106
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• Parathyroid hormone for bone regeneration., PMID:29926970 _x005F_x005F_x000D_ |
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