Anti-Human ST2/IL-33R Reference Antibody (Astegolimab, RUO) (MX139016)

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概述

货号	MX139016
品牌	abinScience
描述	Astegolimab (MX139016) is a research-grade recombinant antibody targeting T1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG2a-kappa
表达系统	Mammalian cells
经测试应用	WB
靶标	T1, DER4, Interleukin-1 receptor-like 1, ST2, IL1RL1, Protein ST2
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q01638
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	AMG-282, MSTT-1041A, RG-6149, RO-7187807, 2173054-79-8
背景	Interleukin-1 receptor-like 1 (IL1RL1/ST2) is a ~63 kDa protein. Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. 1. Yi, XM. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2116279119. PMID: 35238669 2. Schmitz, J. et al. (2005) Immunity 23, 479-90. PMID: 16286016
Note	For research use only.
Isotype Control	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173) (MF533507)

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SDS-PAGE

SDS-PAGE for Research Grade Astegolimab
Bioactivity

Detects recombinant human IL1RL1/ST2 (Catalog No: HX139011) in indirect ELISA
Western blot

Western blot analysis was performed using anti-/ monoclonal antibody at 1ug/mL on various samples.
Lane 1: ATGE3660 200ng
Lane 2: 1* loading buffer

参考文献

产品说明书

Anti-Human ST2/IL-33R Reference Antibody (Astegolimab, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ST2/IL-33R Reference Antibody (Astegolimab, RUO) (MX139016)

概述

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参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ST2/IL-33R Reference Antibody (Astegolimab, RUO) (MX139016)

概述

图片

参考文献

产品说明书

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