Anti-Human NTRK1/TRKA (GBR 900) (HY107016) is a research-grade recombinant antibody targeting Trk-A. Produced in mammalian cells with native-like glycosylation.
Highlights
●Research Grade — For PK/PD studies, assay development, and ADA research.
ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主
Human
同种型
IgG
克隆号
GBR 900
表达系统
Mammalian cells
克隆类型
Monoclonal
靶标
Trk-A, High affinity nerve growth factor receptor, NTRK1, Tropomyosin-related kinase A, Neurotrophic tyrosine kinase receptor type 1, MTC, TRKA, Tyrosine kinase receptor, TRK, p140-TrkA, TRK1-transforming tyrosine kinase protein, gp140trk, Tyrosine kinase receptor A
内毒素水平
< 10 EU/mg
纯度
>95% purity as determined by SDS-PAGE.
纯化方式
Protein A/G purified from cell culture supernatant.
Accession号
P04629
状态
Liquid
保存溶液
0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
GBR-900, GBR900, GBR900
背景
High affinity nerve growth factor receptor (NTRK1/TRKA) is a ~87 kDa protein. Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation.
1. Jing, S. et al. (1992) Neuron 9, 1067-79. PMID: 1281417
2. Tacconelli, A. et al. (2004) Cancer cell 6, 347-60. PMID: 15488758
3. Wehrman, T. et al. (2007) Neuron 53, 25-38. PMID: 17196528
4. Klein, R. et al. (1991) Cell 65, 189-97. PMID: 1849459
6. Tong, Q. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3811-21. PMID: 22649032
7. Anta, B. et al. (2016) The Journal of biological chemistry 291, 19132-45. PMID: 27445338
8. Barker, PA. et al. (1993) The Journal of biological chemistry 268, 15150-7. PMID: 8325889
Note
For research use only. Not suitable for clinical or therapeutic use.
图片
SDS-PAGE
SDS-PAGE for Research Grade Anti-Human NTRK1/TRKA (GBR 900)
